Yang K. Xiang

This study identifies sex-specific cAMP signaling differences in vascular smooth muscle, showing female-specific SR cAMP pools and their hormonal regulation.

This study shows that S-nitrosylation of PKA regulatory subunits by SCAN is required for GPCR-induced PKA activation in heart, brain, and fat tissues.

This paper identifies a mechanism by which amyloid beta potentiates CaV1.2 channels via β2AR, leading to synaptic dysfunction and neurotoxicity, and shows that disrupting this pathway prevents these effects.

This study shows that deleting β2AR in myeloid cells improves cardiac function and reduces fibrosis after heart attack by enhancing efferocytosis of neutrophils.

This study develops PDE3A2-modRNA to restore nuclear cAMP microdomain regulation, reversing pathological cardiac hypertrophy in a mouse model.

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

This study identifies structural features determining G protein coupling specificity at a class A GPCR using a Gi-biased agonist.

This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.

The paper shows neurons in the mouse brain receive nuclear and ribosomal material from oligodendrocytes, which persists into adulthood and occurs in specific brain regions.

This study identifies the THO nuclear export complex as critical for synaptic transcript export, synapse development, and neuronal survival in dopaminergic neurons across species.