PathologybioRxivPreprint
PDE3A2 modRNA Fine-Tunes Nuclear cAMP Microdomains and Reverses Pathological Cardiac Hypertrophy
Wenjing Xiang, Mingwei Lian, Qiuyun Guan…·Ying Wang
This study develops PDE3A2-modRNA to restore nuclear cAMP microdomain regulation, reversing pathological cardiac hypertrophy in a mouse model.
DOI 10.1101/2025.09.30.679675