An organoid platform reveals MEK-PARP co-targeting to enhance radiation response in rectal cancer
Qiyun Xiao, Julian E. Riedesser, Theresa Mulholland, Zhenchong Li, Jonas Buchloh, Philipp Albrecht, Xinchen Yang, Moying Li, Nachiyappan Venkatachalam, Olga Skabkina, Anna Klupsch, Emerich Eichhorn, Li Wang, Sebastian Belle, Nadine Schulte, , Johannes Betge
The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.
Cell Reports Medicine · Aug 1, 2025Peer-reviewedCancer Biology