Sebastian Belle

The paper identifies a fetal-like stem cell trajectory in colorectal cancer using multi-omics and organoid models, linked to poor prognosis and SRC/mTOR dependency.

The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.

This study uses image-based profiling and multi-omics integration to identify morphological axes of variation in colorectal cancer organoids and link them to biological mechanisms and drug responses.