Erica Valentini

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancer

The paper identifies a fetal-like stem cell trajectory in colorectal cancer using multi-omics and organoid models, linked to poor prognosis and SRC/mTOR dependency.

Proliferation and differentiation of intestinal stem cells depends on the zinc finger transcription factor BCL11/Chronophage

This study identifies Cph as a key regulator of intestinal stem cell proliferation and differentiation, showing its role in maintaining ISC and EE populations and remodeling progenitor transcriptomes.

An organoid platform reveals MEK-PARP co-targeting to enhance radiation response in rectal cancer

The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.

Restraining Wnt activation and intestinal tumorigenesis by a Rab35 dependent GTPase relay

This study identifies Rab35 as a tumor suppressor that modulates Wnt signaling through a GTPase relay, highlighting its role in restraining intestinal tumorigenesis.

Epithelial cells of the intestine acquire cell-intrinsic inflammation signatures during ageing

This study shows that aged intestinal epithelial cells exhibit a persistent inflammation signature, marked by MHC class II upregulation and increased chromatin accessibility of inflammation-associated loci.

Glyoxal as alternative fixative for single cell RNA sequencing

This study develops and benchmarks glyoxal as a fixative for scRNA-seq, showing it preserves transcriptomes in Drosophila and human cells with high correlation to unfixed samples.

The drug-induced phenotypic landscape of colorectal cancer organoids

This study uses image-based profiling and multi-omics integration to identify morphological axes of variation in colorectal cancer organoids and link them to biological mechanisms and drug responses.

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

The paper introduces a large-scale CRISPR mutagenesis library in Drosophila for targeted gene disruption, showing high efficiency and revealing new developmentally essential genes.

Gene expression atlas of a developing tissue by single cell expression correlation analysis

The paper develops a new method for analyzing scRNA-seq data based on gene expression correlations to generate a gene expression atlas of the Drosophila wing disc, identifying 824 genes with spatially restricted expression patterns.