Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states
Huikun Wang, Rodolfo J. Flores, Héctor E. Yarur, Aaron Limoges, Héctor Bravo-Rivera, Sanne M. Casello, Niharika Loomba, Juan Enríquez-Traba, Miguel A. Arenivar, Queenie Wang, Robert Philip Ganley, Charu Ramakrishnan, Lief E. Fenno, Yoon Seok Kim, Karl A. Deisseroth, , Hugo A. Tejeda
The paper shows that vmPFC Dyn neurons suppress defensive behaviors by releasing dynorphin in response to threats and promoting fear-related network states.
Neuron · Apr 12, 2024Peer-reviewedNeuroscience