Charu Ramakrishnan

This study identifies Sst-Chodl inhibitory neurons that promote cortical synchrony and sleep by exerting long-range inhibition during low-arousal states.

This paper introduces a new system for activating and recording thousands of neurons over a large field-of-view with pixel-level precision.

The paper identifies directional elements in brain dynamics that encode causal control hierarchies and show robustness to neural state manipulations.

The paper identifies a functional dichotomy in the ventrolateral periaqueductal gray, showing that micro opioid receptor neurons encode nociceptive states while enkephalin-releasing neurons drive pain relief in various contexts.

The paper identifies a cortical circuit in mice modulated by opioids and develops a gene therapy to mimic opioid analgesia for chronic pain.

The paper investigates how environmental novelty affects cortical plasticity during navigation using optogenetic stimulation and calcium imaging in mice.

The paper introduces a method to monitor and control neural activity at cellular resolution in mice, discovering new cell types with unique functional properties.

The paper identifies selective vulnerability of dopamine-glutamate neurons in aging as a mechanism weakening entorhinal dopamine signaling.

This study shows that cholinergic neuron activity promotes both healthy OPC and DMG proliferation through muscarinic receptors, with specific nuclei driving growth in different brain regions.

This study identifies how different subtypes of VTA glutamatergic neurons signal reward and aversion in distinct ways, highlighting unique roles in behavioral salience.

The paper identifies enhancers for spinal motor neurons and develops AAV vectors to target these cells in rodents and macaques, enabling functional studies and potential therapeutic applications.

This study identifies monosynaptic inputs to VTA VGluT2+VGaT+ neurons in mice, revealing diverse brain-wide connections and distinct behavioral outcomes from lateral hypothalamus and superior colliculus inputs.

The paper identifies distinct central amygdala circuits regulating food and water uptake using intersectional genetics and in vivo calcium imaging.

The paper shows that vmPFC Dyn neurons suppress defensive behaviors by releasing dynorphin in response to threats and promoting fear-related network states.

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

This study evaluates how activating Opto1AR in astrocytes affects hippocampal synaptic excitation and inhibition using optogenetic stimulation.

The paper identifies three genetic dopamine subtypes in the substantia nigra pars compacta, each with distinct functional responses to rewards, aversive stimuli, and movement, showing strong correlation between soma and axon signaling within subtypes.

This study identifies PSTN neuron subpopulations that regulate feeding initiation and consumption behaviors in mice during refeeding.

Optogenetic and electrical perturbations in primate motor cortex during reaching show that movement-related neural activity is governed by a self-contained, low-dimensional dynamical subspace causally linked to reach kinematics.

The paper shows that somatic and axonal signaling in dopamine neurons of behaving mice are correlated, challenging previous assumptions about axonal autonomy.

The paper tests if low-power optogenetic stimulation in primate V1 can mimic visual masking effects, finding it reduces detection sensitivity and shows spatial selectivity.

This paper demonstrates an optical brain-computer interface (oBCI) using dendritic calcium signals from rhesus macaques during motor tasks, achieving stable decoding of movement direction.

This study identifies reciprocal GABAergic projections between the lateral hypothalamus and dorsal raphe nucleus that promote wakefulness through mutual inhibition and network activity modulation.

The paper identifies a new retinal interneuron type, the Campana cell, that integrates rod and cone input and has features of both bipolar and amacrine cells.

This study uses high-resolution imaging to show how neurons deform during action potentials, revealing the relationship between electrical signals and mechanical changes.

This study shows that using fetal brain matrix in 3D cultures enhances the functional differentiation of human neural stem cells into neurons and astrocytes.

This paper demonstrates a proof-of-principle for nanoscale optogenetic activation using a focal stimulation approach with switchable light-gated channels.

This paper demonstrates reversible, temporally specific optogenetic inhibition of motor neurons and muscle activity in mice using a light-activated chloride channel.

The paper identifies a specific class of central amygdala neurons that are essential for synaptic plasticity in the lateral amygdala during learning.

The paper introduces SWIFT, a computational imaging method for capturing coordinated neuronal activity across large tissue volumes in mammals at high speed and resolution.