Karl A. Deisseroth

Minerva extracts RNA base-pairing, protein-contact and repeat maps from a genome language model without alignments, flagging unannotated structured loci and a phage ncRNA array reverse-transcribed into short cDNAs.

The paper uses diffusion MRI and SEEG to predict electrophysiological connectivity and explain evoked potential spectral signatures in the human brain.

This paper develops GELYTACs, lysosome-targeting chimeras that deplete IgG in vivo via AAV delivery, showing sustained antibody depletion in mice.

This study identifies Sst-Chodl inhibitory neurons that promote cortical synchrony and sleep by exerting long-range inhibition during low-arousal states.

This study shows that hippocampo-septal feedback inhibits the medial septal circuit based on hippocampal activity and movement speed, without being essential for theta rhythm generation.

This paper introduces CURBD, a method using data-constrained recurrent neural networks to infer brain-wide interactions from neural recordings across species.

This paper introduces a new system for activating and recording thousands of neurons over a large field-of-view with pixel-level precision.

The paper develops a genetically encoded voltage indicator to measure subthreshold voltage dynamics in neurons, revealing electrical diversity and local computation.

This study introduces a new microscopy technique to track neocortical activity with high spatial and temporal resolution, revealing fundamental dynamical elements and their properties across different neural activity regimes.

The paper identifies directional elements in brain dynamics that encode causal control hierarchies and show robustness to neural state manipulations.

This study identifies PSTN Crh neurons as a key driver of alcohol drinking escalation in dependence, showing their role shifts from inhibitory to stimulatory with dependence.

The paper identifies a functional dichotomy in the ventrolateral periaqueductal gray, showing that micro opioid receptor neurons encode nociceptive states while enkephalin-releasing neurons drive pain relief in various contexts.

The paper identifies a cortical circuit in mice modulated by opioids and develops a gene therapy to mimic opioid analgesia for chronic pain.

This study shows serotonergic neurons promote high-grade glioma growth via 5HT2A receptor activation, with psychedelic drugs enhancing this effect.

This study examines thalamoprefrontal circuit signaling in mice and connectivity dynamics in humans during learning, finding conserved mechanisms across species.

The paper develops a platform for continuous behavioral tracking of vertebrates across their lifespan and identifies distinct aging trajectories linked to transcriptomic changes and predictive models of lifespan.

MAPL3 enables whole-brain projectome mapping at single-axon resolution using deep learning and light sheet microscopy, outperforming existing methods across diverse datasets.

The paper investigates how environmental novelty affects cortical plasticity during navigation using optogenetic stimulation and calcium imaging in mice.

The paper introduces a method to monitor and control neural activity at cellular resolution in mice, discovering new cell types with unique functional properties.

The paper identifies selective vulnerability of dopamine-glutamate neurons in aging as a mechanism weakening entorhinal dopamine signaling.

This study shows that cholinergic neuron activity promotes both healthy OPC and DMG proliferation through muscarinic receptors, with specific nuclei driving growth in different brain regions.

This study identifies how different subtypes of VTA glutamatergic neurons signal reward and aversion in distinct ways, highlighting unique roles in behavioral salience.

The paper identifies enhancers for spinal motor neurons and develops AAV vectors to target these cells in rodents and macaques, enabling functional studies and potential therapeutic applications.

This study identifies monosynaptic inputs to VTA VGluT2+VGaT+ neurons in mice, revealing diverse brain-wide connections and distinct behavioral outcomes from lateral hypothalamus and superior colliculus inputs.

The paper identifies distinct central amygdala circuits regulating food and water uptake using intersectional genetics and in vivo calcium imaging.

The paper identifies Ribosome-Associated Vesicles (RAVs) as dynamic platforms that facilitate activity-dependent local translation in neurons by transporting ribosomes to distal processes.

The paper shows that vmPFC Dyn neurons suppress defensive behaviors by releasing dynorphin in response to threats and promoting fear-related network states.

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

This study evaluates how activating Opto1AR in astrocytes affects hippocampal synaptic excitation and inhibition using optogenetic stimulation.

The paper shows that inhibiting VTA dopamine neurons during reward cue presentation prevents sign-tracking behavior, confirming dopamine's role in encoding incentive value.