Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification
Vincent Mouilleau, Célia Vaslin, Rémi Robert, Simona Gribaudo, Nour Nicolas, Margot Jarrige, Angélique Terray, Léa Lesueur, Mackenzie W. Mathis, Gist F. Croft, Mathieu Daynac, V. Rouiller, Hynek Wichterle, Vanessa Ribes, Cécile Martinat, Stéphane Nedelec
This study shows that the HOX clock in human axial progenitors is dynamically paced by extrinsic cues like FGF signaling, enabling controlled motor neuron subtype specification.
Development · Mar 15, 2021Peer-reviewedDevelopmental Biology