Mathieu Daynac

This study uses human iPSC-derived models to show AGTR1 inhibition protects mDA neurons from degeneration and reduces alpha-synuclein pathology.

The paper identifies an immature neuroblast population with plasticity and molecular switches in splicing regulators during neurogenesis.

This study shows that the HOX clock in human axial progenitors is dynamically paced by extrinsic cues like FGF signaling, enabling controlled motor neuron subtype specification.