Stéphane Nedelec

The paper identifies PAX3's role in coupling metabolism and cell mechanics during neuroepithelial morphogenesis, showing mannose metabolism is critical for adherens junction function.

This study investigates how SETX mutations in ALS4 lead to RNA dysregulation and neuronal dysfunction through TGF-β signaling activation and R-loop metabolism disruption.

The paper shows that GPR161 at the primary cilium senses mechanical stimuli to drive cyclic saltatory neuronal migration through cAMP/PKA signaling and NDE1 phosphorylation.

This study compares the role of RPGRIP1L in human and mouse neural progenitor fate specification, finding distinct effects on motoneuron identity and SHH signaling.

This study uses single-cell transcriptomics to identify novel motor neuron subtypes in mice, revealing subtype diversity that increases in land animals and continues to evolve in humans.

This study shows that the HOX clock in human axial progenitors is dynamically paced by extrinsic cues like FGF signaling, enabling controlled motor neuron subtype specification.

This paper introduces a genetic switch called iOn that enables the identification of genomic integration events by triggering gene expression upon insertion, improving transgenesis in stem cells and model organisms.

This study shows that BMP4 exposure creates spatial BMP signalling patterns in spinal organoids, leading to stereotyped dorsal neural tube cell fate organisation in mouse and human.