Vanessa Ribes

Transcriptional coupling of metabolism and cell mechanics controls humanneuroepithelium morphogenesis

The paper identifies PAX3's role in coupling metabolism and cell mechanics during neuroepithelial morphogenesis, showing mannose metabolism is critical for adherens junction function.

An integrated computational, clinical, and functional framework for assessing PTPN11 (SHP2) variant effects on ERK signaling and neural crest cell behavior in Noonan spectrum disorders

The paper assesses PTPN11 variant effects on ERK signaling and neural crest cell behavior in Noonan spectrum disorders through clinical, biochemical, and in vivo analyses.

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development

This study maps the temporal and functional landscape of Sonic Hedgehog signaling in human forebrain development using stem cell models and identifies new markers of regionalization.

Dual PAX3/7 transcriptional activities spatially encode spinal cell fates through distinct gene networks

The paper shows PAX3/7 transcription factors use distinct gene networks to spatially control spinal cell fates through repression and activation mechanisms.

Antero-posterior gradients of cell plasticity and proliferation modulate posterior regeneration in the annelid Platynereis

The paper identifies two progenitor populations in Platynereis regeneration, showing that less differentiated, more proliferative gut progenitors are more plastic but limited in regenerative capacity.

Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification

This study shows that the HOX clock in human axial progenitors is dynamically paced by extrinsic cues like FGF signaling, enabling controlled motor neuron subtype specification.

Transcriptional control of cardiac neural crest cells condensation and outflow tract septation by the Smad1/5/8 inhibitor Dullard

The paper investigates how BMP signaling, through the Smad1/5/8 inhibitor Dullard, regulates cardiac neural crest cell behavior and outflow tract septation in vertebrates.

BMP4 patterns Smad activity and generates stereotyped cell fate organisation in spinal organoids

This study shows that BMP4 exposure creates spatial BMP signalling patterns in spinal organoids, leading to stereotyped dorsal neural tube cell fate organisation in mouse and human.