Hynek Wichterle

The paper identifies how NKX2-2 independently controls neurogenesis and dorsoventral patterning in human spinal progenitors through distinct mechanisms from rodents.

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

This study re-expresses embryonic motor neuron factors in mature neurons to reverse age-related degeneration and reduce ALS symptoms in a mouse model.

This study shows that disrupted MAM function in ALS models leads to altered mitochondrial metabolism, specifically a shift from pyruvate to fatty acid utilization.

The paper maps gene expression and chromatin accessibility changes in mouse spinal motor neurons during maturation, revealing dynamic regulatory elements and shared transcription factor motifs.

The paper identifies a human-specific progenitor sub-domain in the spinal cord that extends neurogenesis and increases motor neuron production compared to mice.

The paper identifies a bipartite imprinting control region at the Dlk1-Dio3 locus that maintains imprint stability through allele-specific regulation of DNA methylation and chromatin structure.

The paper evaluates nine computational methods for identifying and ranking reprogramming factors in directed differentiation, finding that chromatin accessibility-based methods like DeepAccess and AME perform best.

This study shows that the HOX clock in human axial progenitors is dynamically paced by extrinsic cues like FGF signaling, enabling controlled motor neuron subtype specification.

The paper investigates how posterior HOX TFs differ in their ability to bind inaccessible chromatin, leading to distinct gene expression patterns during motor neuron differentiation.

The paper identifies proteostatic differences between ALS-resistant and sensitive motor neurons using stem cell-derived models.

The paper introduces CID, a computational method for chromatin interaction discovery that improves sensitivity and consistency compared to existing methods.