Impact of baseline culture conditions of mouse-derived cancer organoids when determining therapeutic response and tumor heterogeneity
R. A. DeStefanis, A. M. Olson, A. K. DeZeeuw, A. A. Gillette, G. C. Sha, K. A. Johnson, J. D. Kratz, C. A. Pasch, L. Clipson, M. C. Skala, D. A. Deming
This study evaluates how baseline culture conditions affect therapeutic response and heterogeneity in mouse-derived cancer organoids, finding that initial size is the key factor influencing growth and response.
bioRxiv · Oct 12, 2021 · PreprintCancer Biology