Author

D. A. Deming

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:clustering· 2 Organism:human· 2 Organism:mouse· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. A. Pasch· 3 shared M. C. Skala· 3 shared A. A. Gillette· 2 shared A. K. DeZeeuw· 2 shared C. M. Sprackling· 2 shared J. D. Kratz· 2 shared K. A. Johnson· 2 shared K. A. Matkowskyj· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

C. A. Pasch

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment

A. Papadas, G. Deb, A. Officer, A. Cicala, C. Hope, P. Emmerich, J. Wiesner, A. Pagenkopf, G. Arauz, V. Bansal, K. Matkowskyj, D. A. Deming, K. Politi, S. Abrams, O. Harismendy, F. Asimakopoulos

The paper shows that stromal remodeling generates signals that regulate dendritic cell survival and activity, enhancing T-cell inflammation in the tumor microenvironment.

bioRxiv · Nov 10, 2021Immunology

Integrating Subclonal Response Heterogeneity to Define Cancer Organoid Therapeutic Sensitivity

J. D. Kratz, S. Rehman, K. A. Johnson, A. A. Gillette, A. Sunil, P. F. Favreau, C. A. Pasch, D. Miller, L. C. Zarling, A. H. Yeung, L. Clipson, S. J. Anderson, A. K. DeZeeuw, C. M. Sprackling, K. K. Lemmon, , D. A. Deming

The paper evaluates individual patient-derived cancer organoids using optical metabolic imaging to predict therapeutic response and identify subclonal populations and resistance mechanisms.

bioRxiv · Oct 15, 2021 · PreprintCancer Biology

Impact of baseline culture conditions of mouse-derived cancer organoids when determining therapeutic response and tumor heterogeneity

R. A. DeStefanis, A. M. Olson, A. K. DeZeeuw, A. A. Gillette, G. C. Sha, K. A. Johnson, J. D. Kratz, C. A. Pasch, L. Clipson, M. C. Skala, D. A. Deming

This study evaluates how baseline culture conditions affect therapeutic response and heterogeneity in mouse-derived cancer organoids, finding that initial size is the key factor influencing growth and response.

bioRxiv · Oct 12, 2021 · PreprintCancer Biology

Optical Metabolic Imaging of Heterogeneous Drug Response in Pancreatic Cancer Patient Organoids

J. T. Sharick, C. M. Walsh, C. M. Sprackling, C. A. Pasch, A. A. Parikh, K. A. Matkowskyj, D. A. Deming, M. C. Skala

This study uses optical metabolic imaging to predict pancreatic cancer patient treatment response by analyzing cellular heterogeneity in organoids.

bioRxiv · Feb 6, 2019Bioengineering