A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ Treg differentiation
P. Mamontov, R. A. Eberwine, J. Perrigoue, A. Das, J. R. Friedman, J. R. Mora
This study shows that ITK knockdown increases Foxp3+ TREG differentiation and suppressive function in human T cells, suggesting ITK as a target to enhance TREGs in autoimmune diseases.
bioRxiv · Aug 7, 2018Immunology