J. R. Friedman

Human CCDC51 and yeast Mdm33 are functionally conserved mitochondrial inner membrane proteins that demarcate a subset of organelle fission events

This study identifies CCDC51 as a human ortholog of yeast Mdm33, showing they both regulate mitochondrial fission and are conserved in function.

PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX

This paper shows that PPTC7 limits mitophagy by interacting with BNIP3 and NIX, promoting their proteasomal degradation through dynamic, proximal associations.

A DRP-like pseudoenzyme coordinates with MICOS to promote cristae architecture

The paper identifies Mmc1, a DRP-like pseudoenzyme that interacts with MICOS to maintain cristae architecture in S. pombe.

An intermembrane space protein facilitates completion of mitochondrial divisionin yeast

This study identifies Mdi1, an intermembrane space protein in yeast essential for mitochondrial fission, showing that Dnm1/Drp1 requires Mdi1 to complete mitochondrial division.

Resolution doubling in light-sheet microscopy via oblique plane structured illumination

This paper demonstrates isotropic resolution doubling in light-sheet microscopy using oblique plane structured illumination, achieving sub-150nm lateral resolution with reduced phototoxicity and faster volumetric imaging.

The outer mitochondrial membrane protein TMEM11 is a novel negative regulator of BNIP3/BNIP3L-dependent receptor-mediated mitophagy

This study identifies TMEM11 as a negative regulator of BNIP3/BNIP3L-dependent mitophagy, showing its role in mitochondrial morphology and autophagy regulation.

ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation

The paper identifies ER-localized phosphatidylethanolamine synthase (Psd1) as a novel regulator of lipid droplet formation, showing its conserved role across species.

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ Treg differentiation

This study shows that ITK knockdown increases Foxp3+ TREG differentiation and suppressive function in human T cells, suggesting ITK as a target to enhance TREGs in autoimmune diseases.