Author

R. A. Jacob

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CUT&Tag· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Heit· 2 shared E. N. Pawlak· 2 shared J. D. Dikeakos· 2 shared A. D. Nagpal· 1 shared A. M. Vreize· 1 shared B. S. Dirk· 1 shared C. End· 1 shared C. Yin· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

B. Heit

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Long dsRNA mediated RNA interference (dsRNAi) is antiviral in interferon competent mammalian cells

S. L. Semple, R. A. Jacob, K. L. Mossman, S. J. DeWitte-Orr

The paper shows that low-concentration dsRNA can inhibit viral replication in IFN-competent mammalian cells via RNAi, independent of IFN induction.

bioRxiv · Jan 14, 2022 · PreprintImmunology

GATA2 Expression by Intima-Infiltrating Macrophages Drives Early Atheroma Formation

C. Yin, A. M. Vreize, J. Akingbasote, E. N. Pawlak, R. A. Jacob, J. Hu, N. Sharma, J. D. Dikeakos, L. Barra, A. D. Nagpal, B. Heit

The paper identifies GATA2 overexpression in early-stage atherosclerotic macrophages as a driver of functional defects linked to atheroma formation.

bioRxiv · Jul 26, 2019 · PreprintImmunology

PACS-1 and Adaptor Protein-1 Mediate ACTH Trafficking to the Regulated Secretory Pathway

B. S. Dirk, C. End, E. N. Pawlak, L. R. Van Nynatten, R. A. Jacob, B. Heit, J. D. Dikeakos

This study identifies PACS-1 and AP-1 as essential for directing POMC to DCSGs, as their knockdown prevents POMC from being trafficked to these granules.

bioRxiv · Oct 17, 2018Cell Biology