Author

R. A. Okimoto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

S. Nanjo· 2 shared T. G. Bivona· 2 shared T. Kondo· 2 shared C. Luck· 1 shared J. J. Quinn· 1 shared J. S. Weissman· 1 shared K. Yu· 1 shared M. G. Jones· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

S. Nanjo

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Author profile →

4 papers

Recent·Most cited

Transcriptional fidelity enhances cancer cell line selection in pediatric cancers

C. Luck, K. Yu, R. A. Okimoto, M. Sirota

This study evaluates how well cancer cell lines represent pediatric tumors using RNA-seq data, finding that most tumor types best correlate with cell lines of the closest disease type.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma.

R. K. Ponce, N. J. Thomas, N. Q. Bui, T. Kondo, R. A. Okimoto

This study identifies WEE1 as a therapeutic target in CIC-DUX4 sarcomas by showing its dependency on WEE1 activity for survival.

bioRxiv · Jun 21, 2021Cancer Biology

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

J. J. Quinn, M. G. Jones, R. A. Okimoto, S. Nanjo, M. M. Chan, N. Yosef, T. G. Bivona, J. S. Weissman

The paper uses single-cell lineage tracing and RNA-seq to identify diverse metastatic behaviors and their drivers in lung cancer xenografts in mice.

Science · Feb 26, 2021Peer-reviewedCancer Biology

The CIC-DUX4 fusion oncoprotein drives metastasis and tumor growth via distinct downstream regulatory programs and therapeutic targets in sarcoma

R. A. Okimoto, W. Wu, S. Nanjo, V. Olivas, Y. Lin, R. Oyama, T. Kondo, T. G. Bivona

This study identifies ETV4 and CCNE1 as targets of the CIC-DUX4 fusion oncoprotein, showing their roles in sarcoma metastasis and tumor growth, and highlights therapeutic strategies targeting the CCNE-CDK2 complex.

bioRxiv · Nov 21, 2018Cancer Biology