The CIC-DUX4 fusion oncoprotein drives metastasis and tumor growth via distinct downstream regulatory programs and therapeutic targets in sarcoma
R. A. Okimoto, W. Wu, S. Nanjo, V. Olivas, Y. Lin, R. Oyama, T. Kondo, T. G. Bivona
This study identifies ETV4 and CCNE1 as targets of the CIC-DUX4 fusion oncoprotein, showing their roles in sarcoma metastasis and tumor growth, and highlights therapeutic strategies targeting the CCNE-CDK2 complex.
bioRxiv · Nov 21, 2018Cancer Biology