In vitro infection of human lung tissue with SARS-CoV-2: Heterogeneity in host defense and therapeutic response
M. A. Schaller, Y. Sharma, Z. Dupee, D. T. Nguyen, J. M. Uruena, R. A. Smolcheck, J. C. Loeb, T. N. Machuca, J. A. Lednicky, D. Odde, R. F. Campbell, W. G. Sawyer, B. Mehrad
This paper develops an in vitro model using cryopreserved human lung tissue to study SARS-CoV-2 infection and drug responses, revealing donor-specific heterogeneity in viral susceptibility and treatment outcomes.
bioRxiv · Jan 20, 2021 · PreprintMicrobiology