Author

W. G. Sawyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. T. Nguyen· 4 shared A. Pepe· 3 shared D. Pedro· 2 shared E. J. Sayour· 2 shared E. Ogando-Rivas· 2 shared J. Huang· 2 shared P. Castillo· 2 shared R. Liu· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersBiophysics

D. T. Nguyen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds

R. Alonso Matilla, D. I. Pedro, A. Pepe, J. Serrano-Velez, M. Dunne, D. T. Nguyen, W. G. Sawyer, P. P. Provenzano, D. J. Odde

This study identifies that T cells achieve maximal migration speeds by combining bleb formation with adhesion-based forces, challenging the feasibility of adhesion-free migration.

bioRxiv · Oct 29, 2023Biophysics

mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors

P. Castillo, E. Ogando-Rivas, H. Geffrard, A. Pepe, R. Liu, D. T. Nguyen, D. Pedro, D. Zhang, A. DeVries, S. Qdaisat, A. Karachi, M. Rahman, F. Weidert, R. Milner, J. Huang, , E. J. Sayour

The paper develops an mRNA vaccine to predict brain tumor response to checkpoint inhibitors by analyzing cytokine release patterns in vitro.

bioRxiv · Mar 18, 2023 · PreprintCancer Biology

Three-Dimensional Bioconjugated Liquid-Like Solid (LLS) Enhance Characterization of Solid Tumor - Chimeric Antigen Receptor T cell Interactions

D. T. Nguyen, R. Liu, E. Ogando-Rivas, A. Pepe, D. Pedro, S. Qdaisat, T. Y. N. Nguyen, J. Lavrador, G. Golde, R. Smolcheck, J. Ligon, L. Jin, H. Tao, A. Webber, S. Phillpot, , W. G. Sawyer

This study uses 3D bioconjugated liquid-like solids to model tumor-immune interactions, showing CAR T cells can infiltrate and kill cancer cells while revealing immune escape mechanisms.

bioRxiv · Feb 17, 2023 · PreprintBioengineering

In vitro infection of human lung tissue with SARS-CoV-2: Heterogeneity in host defense and therapeutic response

M. A. Schaller, Y. Sharma, Z. Dupee, D. T. Nguyen, J. M. Uruena, R. A. Smolcheck, J. C. Loeb, T. N. Machuca, J. A. Lednicky, D. Odde, R. F. Campbell, W. G. Sawyer, B. Mehrad

This paper develops an in vitro model using cryopreserved human lung tissue to study SARS-CoV-2 infection and drug responses, revealing donor-specific heterogeneity in viral susceptibility and treatment outcomes.

bioRxiv · Jan 20, 2021 · PreprintMicrobiology