Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging
R. Angelini, E. Yutuc, M. F. Wyatt, J. Newton, F. A. Yusuf, L. Griffiths, B. J. Cooze, D. El Assad, G. Frache, W. Rao, L. B. Allen, Z. Korade, T. T. Nguyen, R. A. Rathnayake, S. M. Cologna, , W. J. Griffiths
This study uses mass spectrometry imaging to visualize cholesterol distribution in mouse brain tissue, showing reduced cholesterol in specific regions of NPC1 disease models and during development.
bioRxiv · Nov 6, 2020 · PreprintBiochemistry