T. T. Nguyen

Emergent collective alignment gives competitive advantage to longer cells during range expansion

The paper shows longer bacterial cells gain a competitive advantage during range expansion through collective alignment, blocking shorter cells from resources.

Propagation of a rapid cell-to-cell H2O2 signal over long distances in a monolayer of cardiomyocyte cells

The paper identifies a rapid long-distance H2O2 signaling pathway in cardiomyocyte monolayers that involves superoxide production, gap junctions, and protein abundance changes.

Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism

This study shows physical activity reduces breast cancer risk by improving HSC function and enhancing cancer immunosurveillance through reduced oxidative stress and altered T cell differentiation.

Chimeric oncolytic adenovirus evades neutralizing antibodies from human patients and exhibits enhanced anti-glioma efficacy in immunized mice

This paper develops a chimeric oncolytic adenovirus that evades neutralizing antibodies and shows improved anti-glioma efficacy in mice.

Combination fedratinib and venetoclax has activity against human B-ALL with high FLT3 expression

This study shows that combining fedratinib and venetoclax effectively kills B-ALL cells with high FLT3 expression, both in vitro and in vivo.

CISD3 is required for Complex I function, mitochondrial integrity, and skeletal muscle maintenance

This study shows that CISD3 deficiency in mice causes muscle atrophy and mitochondrial dysfunction, revealing its role in Complex I function and muscle maintenance.

A rapid genome-wide analysis of isolated giant viruses only using MinION sequencing

This study demonstrates that MinION-only sequencing can accurately assemble giant virus genomes, enabling rapid genome-wide analysis of newly isolated viruses.

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

The paper identifies a metabolic vulnerability in specific glioma cell states that can be targeted with GPX4 inhibitors to induce ferroptosis.

The effects of multifactorial stress combination on rice and maize

This study shows that multifactorial stress combinations negatively affect rice and maize growth, with proteomics revealing common stress-responsive proteins.

Novel EGFR-Mutant Mouse Models of Lung Adenocarcinoma Reveal Adaptive Immunity Requirement for Durable Osimertinib Response

An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion

This study identifies Aphyd as an ER membrane protein that regulates both fission and fusion machinery recruitment to ER-mitochondria contact sites by altering phospholipid composition.

Testis-specific H2BFWT disrupts nucleosome integrity through reductions of DNA-histone interactions

This study identifies H2BFWT's role in spermatogenesis by showing its impact on nucleosome stability and gene expression through structural and functional analyses.

Adaptive immunity is required for durable responses to alectinib in murine models of EML4-ALK lung cancer

This paper shows that adaptive immunity enhances the durability of alectinib response in EML4-ALK lung cancer models, with CD8+ T cells playing a key role.

Magnetic torque-driven living microrobots for enhanced tumor infiltration

This study demonstrates that magnetic torque-driven motion enhances infiltration of living microrobots across physiological barriers both in vitro and in vivo.

Hepatitis C Virus Infects and Perturbs Liver Stem Cells

This study identifies liver stem cells as targets of HCV infection, showing their transcriptional reprogramming and role in liver damage and cancer risk.

PRE-CLINICAL IMMUNE RESPONSE AND SAFETY EVALUATION OF THE PROTEIN SUBUNIT VACCINE NANOCOVAX FOR COVID-19

This study evaluates the immune response and safety of the protein subunit vaccine Nanocovax in animal models, showing high immunogenicity and no adverse effects.

Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging

This study uses mass spectrometry imaging to visualize cholesterol distribution in mouse brain tissue, showing reduced cholesterol in specific regions of NPC1 disease models and during development.

Evolutionary history of Carnivora (Mammalia, Laurasiatheria) inferred from mitochondrial genomes

This study uses mitochondrial genomes to reconstruct the evolutionary history of Carnivora, identifying divergence times and resolving phylogenetic relationships among major groups.

Reengineering the Specificity of the Highly Selective Clostridium botulinum Protease via Directed Evolution

This study uses directed evolution to reengineer the BoNT/A protease to target SNAP23, improving its cleavage specificity and catalytic efficiency for therapeutic applications.

Mapping of safe and early chemo-attenuated live Plasmodium falciparum immunization identifies immune signature of vaccine efficacy

This study evaluates the safety and efficacy of chemo-attenuated Plasmodium falciparum immunization, identifying immune signatures that correlate with vaccine protection.

Overexpression of blaOXA-58 Gene Driven by ISAba3 is Associated with Imipenem Resistance in a Clinical Acinetobacter baumannii Isolate from Vietnam

This study identifies an Acinetobacter baumannii isolate with ISAba3-blaOXA-58 gene structure that overexpresses blaOXA-58, leading to imipenem resistance and high periplasmic beta-lactamase activity.

Data-driven inference of crosstalk in the tumor microenvironment

The paper develops a data-driven method to deconvolute bulk tumor transcriptomes and predict cancer-stromal crosstalk in 20 solid tumor types, revealing new insights into signaling patterns.

Isoform-specific aPKC renders primary cilia dispensable for Hedgehog signaling and basal cell carcinoma growth

The paper shows that aPKC isoforms sustain HH signaling and BCC growth without primary cilia by compensating for ciliary loss in advanced cancers.

Protein complex stoichiometry and expression dynamics of transcription factors modulate stem cell division

The paper models SHR-SCR complex stoichiometry and regulation to explain differences in division timing between QC and CEI in Arabidopsis root stem cells.

Phosphoproteomics of Arabidopsis Highly ABA-Induced1 identifies AT-Hook Like10 phosphorylation required for stress growth regulation

This study identifies HAI1-regulated phosphorylation sites in Arabidopsis, showing AHL10 S314 phosphorylation controls growth and stress responses.

Antibiotic-induced dysbiosis predicts mortality in an animal model of Clostridium difficile infection

This study shows that antibiotic-induced dysbiosis predicts mortality in a C. difficile infection model using hamsters.

American Gut: an Open Platform for Citizen-Science Microbiome Research

The paper uses citizen-science data to analyze human stool microbiomes, revealing new insights into microbial diversity, metabolome composition, and associations with diet and health.