Author

J. Newton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. G. Sikora· 1 shared A. Lindemann· 1 shared B. J. Cooze· 1 shared B. Uzunparmak· 1 shared C. R. Pickering· 1 shared D. El Assad· 1 shared E. Lin· 1 shared E. Yutuc· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. G. Sikora

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Author profile →

3 papers

Recent·Most cited

Loss of Caspase-8 function in combination with SMAC mimetic treatment sensitizes Head and Neck Squamous Carcinoma to radiation through induction of necroptosis

B. Uzunparmak, M. Gao, A. Lindemann, K. Erikson, L. Wang, E. Lin, S. Frank, F. O. Gleber-Netto, M. Zhao, H. D. Skinner, J. Newton, A. G. Sikora, J. N. Myers, C. R. Pickering

This study shows that loss of CASP8 function combined with SMAC mimetic treatment increases necroptosis in HNSCC, enhancing radiation sensitivity.

JCI Insight · Dec 3, 2020Peer-reviewedCancer Biology

Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging

R. Angelini, E. Yutuc, M. F. Wyatt, J. Newton, F. A. Yusuf, L. Griffiths, B. J. Cooze, D. El Assad, G. Frache, W. Rao, L. B. Allen, Z. Korade, T. T. Nguyen, R. A. Rathnayake, S. M. Cologna, , W. J. Griffiths

This study uses mass spectrometry imaging to visualize cholesterol distribution in mouse brain tissue, showing reduced cholesterol in specific regions of NPC1 disease models and during development.

bioRxiv · Nov 6, 2020 · PreprintBiochemistry

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain

J. Newton, G. Y. Li, M. T. Naik, N. L. Fawzi, J. M. Sedivy, G. Jogl

This paper shows that the N-terminus and coiled-coil domain of ORF1 protein mediate phase separation, which may protect L1 transcripts from degradation.

bioRxiv · Oct 29, 2020Biophysics