Author

W. J. Griffiths

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Assay:metabolomics· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

E. Yutuc· 3 shared Y. Wang· 3 shared C. A. Thornton· 2 shared A. Dickson· 1 shared A. L. Dickson· 1 shared B. J. Cooze· 1 shared D. El Assad· 1 shared F. A. Yusuf· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

E. Yutuc

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Author profile →

3 papers

Recent·Most cited

HSD3B1 is an Oxysterol 3β-Hydroxysteroid Dehydrogenase in Human Placenta

A. Dickson, E. Yutuc, C. A. Thornton, J. E. Dunford, U. Oppermann, Y. Wang, W. J. Griffiths

The paper identifies HSD3B1 as an enzyme in human placenta that converts oxysterols into 3-oxo-4-ene derivatives, which are found in umbilical cord and maternal plasma.

bioRxiv · Apr 1, 2022Biochemistry

Identification of Unusual Oxysterols Biosynthesised in Human Pregnancy by Charge-Tagging and Liquid Chromatography - Mass Spectrometry

A. L. Dickson, E. Yutuc, C. A. Thornton, Y. Wang, W. J. Griffiths

This study identifies 20S-hydroxycholesterol and proposes a novel pathway for C27 bile acid synthesis in pregnancy-related fluids.

bioRxiv · Feb 7, 2022Biochemistry

Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging

R. Angelini, E. Yutuc, M. F. Wyatt, J. Newton, F. A. Yusuf, L. Griffiths, B. J. Cooze, D. El Assad, G. Frache, W. Rao, L. B. Allen, Z. Korade, T. T. Nguyen, R. A. Rathnayake, S. M. Cologna, , W. J. Griffiths

This study uses mass spectrometry imaging to visualize cholesterol distribution in mouse brain tissue, showing reduced cholesterol in specific regions of NPC1 disease models and during development.

bioRxiv · Nov 6, 2020 · PreprintBiochemistry