Non-deletional CD8+ T cell self-tolerance permits responsiveness but limits tissue damage
E. N. Truckenbrod, K. S. Burrack, T. P. Knutson, H. Borges da Silva, K. E. Block, K. R. Stagliano, A. A. Hurwitz, R. B. Fulton, K. Renkema, S. C. Jameson
The paper shows that self-tolerant CD8+ T cells can respond but limit tissue damage, with functional tolerance linked to reduced CD25 expression and gene expression profiles.
bioRxiv · Dec 16, 2020Immunology