ImmunologybioRxiv
Non-deletional CD8+ T cell self-tolerance permits responsiveness but limits tissue damage
E. N. Truckenbrod, K. S. Burrack, T. P. Knutson…·S. C. Jameson
The paper shows that self-tolerant CD8+ T cells can respond but limit tissue damage, with functional tolerance linked to reduced CD25 expression and gene expression profiles.