Author

H. Borges da Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. C. Jameson· 3 shared C. Peng· 2 shared K. M. Wanhainen· 2 shared S. van Dijk· 2 shared T. Vardam-Kaur· 2 shared A. A. Hurwitz· 1 shared A. Banuelos· 1 shared A. S. Beniwal· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

S. C. Jameson

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3 papers

Recent·Most cited

The ATP-exporting channel Pannexin-1 promotes CD8+ T cell effector and memory responses

T. Vardam-Kaur, A. Banuelos, M. Gabaldon-Parish, B. G. Macedo, C. L. Salgado, K. M. Wanhainen, M. H. Zhou, S. van Dijk, I. Santiago-Carvalho, A. S. Beniwal, C. L. Leff, C. Peng, N. L. Tran, S. C. Jameson, H. Borges da Silva

This study shows that Pannexin-1 promotes CD8+ T cell effector and memory responses through distinct mechanisms involving eATP export and purinergic receptor activation.

bioRxiv · Apr 19, 2023Immunology

The extracellular ATP receptor P2RX7 imprints a pro-memory transcriptional signature in effector CD8+ T cells

T. Vardam-Kaur, S. van Dijk, C. Peng, K. M. Wanhainen, S. C. Jameson, H. Borges da Silva

This study shows that P2RX7 expression in effector CD8+ T cells influences their differentiation into central and resident memory cells through transcriptional changes.

bioRxiv · May 25, 2021 · PreprintImmunology

Non-deletional CD8+ T cell self-tolerance permits responsiveness but limits tissue damage

E. N. Truckenbrod, K. S. Burrack, T. P. Knutson, H. Borges da Silva, K. E. Block, K. R. Stagliano, A. A. Hurwitz, R. B. Fulton, K. Renkema, S. C. Jameson

The paper shows that self-tolerant CD8+ T cells can respond but limit tissue damage, with functional tolerance linked to reduced CD25 expression and gene expression profiles.

bioRxiv · Dec 16, 2020Immunology