Author

T. P. Knutson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Organism:human· 2

Frequent Co-Authors

M. A. Farrar· 3 shared R. S. LaRue· 3 shared L. M. Heltemes-Harris· 2 shared S. A. Munro· 2 shared A. A. Hurwitz· 1 shared A. C. Nelson· 1 shared A. L. Sarver· 1 shared B. McClusky· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

M. A. Farrar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Influenza infection recruits distinct waves of regulatory T cells to the lung that limit lung resident IgA+ B cells

L. E. Sjaastad, D. L. Owen, S. Joo, T. P. Knutson, C. H. O'Connor, B. McClusky, R. S. LaRue, R. A. Langlois, M. A. Farrar

This study identifies two distinct regulatory T cell subsets in the lung during influenza infection and shows their role in modulating IgA+ B cells, with similar patterns observed in COVID-19 patients.

bioRxiv · Sep 19, 2022 · PreprintImmunology

Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients.

S. E. Tarullo, Y. He, C. Daughters, T. P. Knutson, C. Henzler, M. Price, R. Shanley, P. Witschen, C. Tolg, R. E. Kaspar, C. Hallstrom, L. Gittsovich, M. L. Sulciner, X. Zhang, C. Forester, , A. C. Nelson

This study identifies RHAMM as a marker of invasive niches in breast cancer, showing its association with poor outcomes and promoting invasion through a 27-gene signature.

bioRxiv · Jun 13, 2022Cancer Biology

Non-deletional CD8+ T cell self-tolerance permits responsiveness but limits tissue damage

E. N. Truckenbrod, K. S. Burrack, T. P. Knutson, H. Borges da Silva, K. E. Block, K. R. Stagliano, A. A. Hurwitz, R. B. Fulton, K. Renkema, S. C. Jameson

The paper shows that self-tolerant CD8+ T cells can respond but limit tissue damage, with functional tolerance linked to reduced CD25 expression and gene expression profiles.

bioRxiv · Dec 16, 2020Immunology

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia

L. M. Heltemes-Harris, G. Hubbard, R. S. LaRue, S. A. Munro, T. P. Knutson, R. Yang, C. M. Henzler, T. K. Starr, A. L. Sarver, s. M. Kornblau, M. A. Farrar

This study identifies cooperating mutations that drive leukemia in mice with B cell transcription factor defects and suggests PDK1 inhibitors as potential therapies.

bioRxiv · Nov 25, 2020Cancer Biology

Single-cell analysis of developing B cells reveals dynamic gene expression networks that govern B cell development and transformation

R. Lee, S. A. Munro, T. P. Knutson, R. S. LaRue, L. M. Heltemes-Harris, M. A. Farrar

The paper uses single-cell transcriptomics and proteomics to study B cell development, identifying novel proliferative phases and dynamic gene expression patterns linked to B cell transformation.

bioRxiv · Jun 30, 2020 · PreprintImmunology