SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma
M. M. Khan, N. Boufaied, M. Yeganeh, A. Ghosh, R. Kandhi, R. Bagheri, S. Petkiewicz, A. Sharma, A. Yoshimura, G. Ferbeyre, D. P. Labbe, S. Ramanathan, S. Ilangumaran
The paper shows that SOCS1 deficiency leads to increased SOCS3 expression, which activates the p53-p21-NRF2 axis, reducing oxidative stress and HCC progression.
bioRxiv · Oct 21, 2021 · PreprintCancer Biology