M. M. Khan

In-host evolution of classic to convergent Klebsiella pneumoniae sequence type 147 isolates and impact of associated capsular changes on different morphotypes

This study investigates in-host evolution of Klebsiella pneumoniae sequence type 147 isolates, revealing microevolution from classic to convergent pathotype through plasmid acquisition and capsular changes affecting virulence and morphology.

HIC1 interacts with FOXP3 multi-protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function

This study identifies HIC1 as part of a FOXP3-RUNX1-CBFB complex that regulates Treg cell differentiation and function through interactions with the RUNX1 promoter.

Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in ex-vivo and in vitro models of pulmonary fibrosis

This study shows Dextromethorphan reduces collagen deposition in fibrotic models by inhibiting collagen trafficking in the endoplasmic reticulum.

In Silico Evaluation of Biomarker Genes for Melanoma Carcinoma

The paper identifies 17 up-regulated biomarkers for psoriasis-related melanoma using computational analysis of gene expression data and network biology.

Spatiotemporal dynamics of DNA repair proteins between the Golgi and nucleus maintain genomic stability.

The paper identifies dynamic redistribution of DNA repair proteins between the Golgi and nucleus in response to DNA damage, revealing a spatiotemporal coordination role for the Golgi in maintaining genomic stability.

Quantitative imaging reveals PI3Kδ inhibition reduces rhinovirus-induced damage of small airway epithelia in ex vivo cultured human precision cut lung slices from COPD patients

SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma

The paper shows that SOCS1 deficiency leads to increased SOCS3 expression, which activates the p53-p21-NRF2 axis, reducing oxidative stress and HCC progression.

A high throughput SEC23 functional interaction screen reveals a role for focal adhesion and extracellular matrix signalling in the regulation of COPII subunit SEC23A

The paper screens 378 cytoskeleton-associated proteins for functional interactions with COPII subunits SEC23A and SEC23B, identifying regulators linked to focal adhesion and ECM signaling.

Quantitative analysis and genome-scale modeling of human CD4+ T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways

This study uses genome-scale modeling and lipidomics to show that glycosphingolipid pathways are specifically regulated in Th17 cells during differentiation and are critical for their effector functions.

Multiomic and quantitative label-free microscopy-based analysis of ex vivo culture and TGFbeta1 stimulation of human precision-cut lung slices

The paper uses multiomic and microscopy techniques to study fibrosis in human lung slices, showing increased collagen deposition with TGFbeta1 stimulation and a novel SHG-based method to quantify it.