Author

R. C. Vignogna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:whole-genome sequencing· 4 Organism:yeast· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

G. I. Lang· 4 shared K. J. Fisher· 2 shared S. W. Buskirk· 2 shared D. A. Marad· 1 shared E. O. Perlstein· 1 shared G. Andreotti· 1 shared J. W. Norris· 1 shared M. Allocca· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersEvolutionary Biology

G. I. Lang

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Author profile →

4 papers

Recent·Most cited

Experimental evolution of phosphomannomutase-deficient yeast reveals compensatory mutations in a phosphoglucomutase

R. C. Vignogna, M. Allocca, M. Monticelli, J. W. Norris, R. Steet, G. Andreotti, E. O. Perlstein, G. I. Lang

This study uses experimental evolution in yeast to identify compensatory mutations that alleviate the effects of human disease-associated PMM2 mutations.

bioRxiv · Apr 6, 2022Evolutionary Biology

Overdominant mutations restrict adaptive loss of heterozygosity at linked loci

K. J. Fisher, R. C. Vignogna, G. I. Lang

The paper shows that overdominant mutations limit loss of heterozygosity at linked loci in yeast, leading to varied evolutionary outcomes.

bioRxiv · May 13, 2021Evolutionary Biology

Exploring a local genetic interaction network using evolutionary replay experiments

R. C. Vignogna, S. W. Buskirk, G. I. Lang

The paper uses evolutionary replay experiments to identify and validate positive genetic interactions involving KEL1 mutations in yeast, showing these interactions are not detected by loss-of-function methods.

Molecular Biology and Evolution · Mar 22, 2021Peer-reviewedEvolutionary Biology

Cause and consequences of genome duplication in haploid yeast populations

K. J. Fisher, S. W. Buskirk, R. C. Vignogna, D. A. Marad, G. I. Lang

This study shows that genome duplication in haploid yeast provides immediate fitness benefits but reduces long-term adaptability.

bioRxiv · Jan 12, 2018Evolutionary Biology