G. I. Lang

Long-term adaptation to galactose as a sole carbon source selects for mutations in nutrient signaling pathways

Experimental evolution of phosphomannomutase-deficient yeast reveals compensatory mutations in a phosphoglucomutase

This study uses experimental evolution in yeast to identify compensatory mutations that alleviate the effects of human disease-associated PMM2 mutations.

Overdominant and partially dominant mutations drive short-term adaptation in diploid yeast

The paper identifies adaptive mutations in diploid yeast by analyzing fitness effects of evolved mutations and finds that overdominant and partially dominant mutations contribute to short-term adaptation.

Overdominant mutations restrict adaptive loss of heterozygosity at linked loci

The paper shows that overdominant mutations limit loss of heterozygosity at linked loci in yeast, leading to varied evolutionary outcomes.

Exploring a local genetic interaction network using evolutionary replay experiments

The paper uses evolutionary replay experiments to identify and validate positive genetic interactions involving KEL1 mutations in yeast, showing these interactions are not detected by loss-of-function methods.

Adaptive evolution of nontransitive fitness in yeast

The paper studies nontransitive fitness evolution in yeast, showing that adaptive mutations in nuclear and viral genomes lead to nontransitive interactions where evolved clones outcompete ancestors but lose to distant ancestors.

Cause and consequences of genome duplication in haploid yeast populations

This study shows that genome duplication in haploid yeast provides immediate fitness benefits but reduces long-term adaptability.

Restricted access to beneficial mutations slows adaptation and biases fixed mutations in diploids

This study shows that diploid yeast adaptation is slower and biased towards dominant mutations due to restricted access to beneficial mutations.

Hitchhiking and epistasis give rise to cohort dynamics in adapting populations

The paper identifies non-adaptive mutations and synergistic epistasis in yeast populations using bulk-segregant analysis of 11 lineages.