Author

R. Castonguay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

D. J. Bernard· 2 shared L. Ongaro· 2 shared E. Belcheva· 1 shared E. Brule· 1 shared E. C. Kappes· 1 shared E. J. Goebel· 1 shared E. R. S. Buddle· 1 shared G. H. Su· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

D. J. Bernard

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Myostatin is a major endocrine driver of follicle-stimulating hormone synthesis

L. Ongaro, X. Zhou, Y. Wang, Z. Zhou, H. Schultz, E. R. S. Buddle, E. Brule, Y.-F. Lin, G. Schang, R. Castonguay, Y. Liu, G. H. Su, N. Seidah, K. C. Ray, S. J. Karp, , D. J. Bernard

The paper identifies myostatin as an endocrine hormone that promotes pituitary FSH synthesis and ovarian function, challenging the previous role of activins and highlighting potential fertility risks of myostatin antagonists.

bioRxiv · Aug 30, 2023 · PreprintPhysiology

The orphan ligand, Activin C, signals through activin receptor-like kinase 7

E. J. Goebel, L. Ongaro, E. C. Kappes, E. Belcheva, R. Castonguay, R. Kumar, D. J. Bernard, T. Thompson

This study characterizes the signaling properties of Activin C and its heterodimer ActAC, showing they activate SMAD2/3 via ALK7 with distinct receptor and antagonist profiles compared to ActA and ActB.

bioRxiv · Mar 16, 2022Biochemistry