Author

Y.-F. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Physiology· 2 Cancer Biology· 1 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 3 Assay:metagenomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. J. Bernard· 3 shared D. Z. Hoh· 2 shared I. J. Tsai· 2 shared P. Ly· 2 shared X. Zhou· 2 shared Y. Wang· 2 shared A. B. Taylor· 1 shared A. C. Hanyaloglu· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersPhysiology

D. J. Bernard

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structures of TGF-beta with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling

L. Wieteska, A. B. Taylor, E. Punch, J. A. Coleman, I. O. Conway, Y.-F. Lin, C.-H. Byeon, C. S. Hinck, T. Krzysiak, R. Ishima, F. Lopez-Casillas, P. Cherepanov, D. J. Bernard, C. S. Hill, A. P. Hinck

This study determines the structure of TGF-beta bound to betaglycan and its signaling receptors, revealing mechanisms of ligand selectivity and signal potentiation.

bioRxiv · Jul 19, 2024 · PreprintBiophysics

An acidophilic fungus is integral to prey digestion in a carnivorous plant

P.-F. Sun, M. R. Lu, Y.-C. Liu, Y.-f. Lin, D. Z. Hoh, H.-M. Ke, I.-F. Wang, M.-Y. J. Lu, R. Kirschner, Y.-C. J. Lin, Y.-L. Chen, I. J. Tsai

This study identifies an acidophilic fungus as a key player in prey digestion by a carnivorous plant, showing gene co-option and synergistic effects in digestion.

bioRxiv · Nov 7, 2023 · PreprintMicrobiology

Myostatin is a major endocrine driver of follicle-stimulating hormone synthesis

L. Ongaro, X. Zhou, Y. Wang, Z. Zhou, H. Schultz, E. R. S. Buddle, E. Brule, Y.-F. Lin, G. Schang, R. Castonguay, Y. Liu, G. H. Su, N. Seidah, K. C. Ray, S. J. Karp, , D. J. Bernard

The paper identifies myostatin as an endocrine hormone that promotes pituitary FSH synthesis and ovarian function, challenging the previous role of activins and highlighting potential fertility risks of myostatin antagonists.

bioRxiv · Aug 30, 2023 · PreprintPhysiology

Mitotic clustering of pulverized chromosomes from micronuclei

Y.-F. Lin, J. E. Valle-Inclan, A. Mazzagatti, Q. Hu, E. G. Maurais, A. Guyer, J. T. Sanders, J. Engel, G. Nguyen, D. Bronder, S. F. Bakhoum, I. Cortes-Ciriano, P. Ly

This study shows that acentric chromosome fragments from micronuclei cluster during mitosis, leading to biased inheritance and balanced chromothripsis in cancer.

Nature · Jun 29, 2023Peer-reviewedCell Biology

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

D. D. Shi, M. R. Savani, M. M. Levitt, A. C. Wang, J. E. Endress, C. E. Bird, J. Buehler, S. A. Stopka, M. S. Regan, Y.-F. Lin, W. Gao, J. Khanal, M. Xu, B. Huang, R. B. Jennings, , McBray

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

bioRxiv · Nov 30, 2021Cancer Biology

Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

C. Toufaily, J. Fortin, C. A. I. Alonso, E. Lapointe, X. Zhou, Y. Santiago-Andres, Y.-F. Lin, Y. Cui, Y. Wang, D. Devost, F. Roelfsema, F. Steyn, A. C. Hanyaloglu, T. Hebert, T. Fiordelisio, , D. J. Bernard

This study shows that adding a C-terminal tail to the tailless murine GnRHR impairs fertility by reducing FSH production and ovarian follicle development.

bioRxiv · Sep 13, 2021Physiology

Apical Actin-myosin Network Regulates the Tight Junction of Polarized Madin-Darby Canine Kidney Cells

C.-h. Lu, F.-l. Wen, S. C.-C. Hsueh, W.-h. Wu, Y.-F. Lin, M. Prouveur, T. Boudier, K.-h. Lin

This study shows that the apical actin network regulates tight junction morphology and permeability through in-plane tension in MDCK cells.

bioRxiv · May 30, 2021 · PreprintBiophysics

Circulating microRNA-762 upregulates colorectal cancer might through Wnt-1/b-catenin signaling

P.-S. Lai, W.-M. Chang, Y.-Y. Chen, Y.-F. Lin, H.-F. Liao, C.-Y. Chen

This study identifies miR-762 as a biomarker upregulating CRC growth and invasion via Wnt-β-catenin signaling in mice and human patients.

bioRxiv · Apr 22, 2020 · PreprintCell Biology

Nest microbiota and pathogen abundance impact hatching success in sea turtle conservation

D. Z. Hoh, Y.-f. Lin, W.-A. Liu, S. N. M. Sidique, I. J. Tsai

The paper investigates how nest microbiota and pathogen abundance affect hatching success in sea turtle hatcheries, finding that reusing sand increases FSSC infection and reduces hatching success.

bioRxiv · Sep 20, 2019Ecology