Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment
K. Hoffmann, H. Berger, H. Kulbe, S. Thillainadarasan, H.-J. Mollenkopf, T. Zemojtel, E. Taube, S. Darb-Esfahani, M. Mangler, J. Sehouli, R. Chekerov, E. Braicu, T. F. Meyer, M. Kessler
This study shows that HGSOC organoids require a low Wnt environment for growth, similar to genetically altered FT organoids, indicating early niche changes support tumor outgrowth.
bioRxiv · Aug 21, 2019Cancer Biology