T. F. Meyer

Inhibition of ADAM17 increases cytotoxic effect of cisplatin in cervical spheroids and organoids

This study shows that inhibiting ADAM17 enhances cisplatin's cytotoxic effect in cervical cancer spheroids and organoids, suggesting ADAM17 as a potential target for overcoming chemoresistance.

Helicobacter pylori cancer associated CagA protein drives intestinal metaplastic transition in human gastric organoids

This study shows that Helicobacter pylori's CagA protein induces intestinal metaplasia in human gastric organoids by activating STAT3 and increasing intestinal markers.

γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

This study evaluates γδ T cell-mediated cytotoxicity against cervical organoids, finding that HPV-transformed and cancerous organoids are more susceptible than healthy ones.

Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids

This study shows that Chlamydia coinfection with HPV disrupts cellular and genomic integrity safeguards in ectocervical organoids, promoting neoplastic progression.

Colibactin DNA damage signature indicates causative role in colorectal cancer

The paper identifies a mutational signature caused by colibactin in human colorectal cancers.

Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment

This study shows that HGSOC organoids require a low Wnt environment for growth, similar to genetically altered FT organoids, indicating early niche changes support tumor outgrowth.

Transition of Wnt signaling microenvironment delineates the squamo-columnar junction and emergence of squamous metaplasia of the cervix

The paper identifies that Wnt signaling dynamics in the stroma regulate the squamo-columnar junction and the emergence of squamous metaplasia in the cervix, without a localized stem cell population at the boundary.

ADP heptose, a novel pathogen-associated molecular pattern associated with Helicobacter pylori type 4 secretion

The paper identifies ADP heptose as the key PAMP in Helicobacter pylori that activates NF-κB via the Alpk1-TIFA axis, showing 100-fold stronger activity than previously proposed HBP.