Author

R. Cohn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. T. Hinson· 3 shared E. Meredith· 2 shared K. Thakar· 2 shared Y.-s. Chen· 2 shared A. C. T. Teng· 1 shared A. Lowe· 1 shared A. M. Pettinato· 1 shared A. O. Gramolini· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

J. T. Hinson

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4 papers

Recent·Most cited

An Efficient and Cost-effective Purification Methodology for Cas9 Nuclease

A. C. T. Teng, M. Tavassoli, S. Shrestha, K. Lindsay, E. Ivakine, R. Cohn, J. P. Santerre, A. O. Gramolini

This paper introduces a rapid, efficient, and cost-effective method to purify active SaCas9 protein with over 90% purity within 24 hours.

bioRxiv · Jun 8, 2021 · PreprintBiochemistry

Adult fibroblasts retain organ-specific transcriptomic identity

E. Forte, M. Ramialison, H. T. Nim, M. Mara, R. Cohn, S. L. Daigle, S. Boyd, J. T. Hinson, M. W. Costa, N. A. Rosenthal, M. B. Furtado

This study shows fibroblasts retain organ-specific transcriptomic identity across development, culture, and transplants, with implications for targeted fibrotic disease treatment.

bioRxiv · Jun 3, 2021Cell Biology

Identifying cardiac actinin interactomes reveals sarcomere crosstalk with RNA-binding proteins

F. A. Ladha, K. Thakar, A. M. Pettinato, N. Legere, R. Cohn, R. Romano, E. Meredith, Y.-s. Chen, J. T. Hinson

The paper identifies cardiac actinin interactomes, revealing sarcomere crosstalk with RNA-binding proteins like IGF2BP2 that affect mitochondrial function and sarcomere assembly.

bioRxiv · Mar 18, 2020Cell Biology

A contraction stress model of hypertrophic cardiomyopathy due to thick filament sarcomere mutations

R. Cohn, K. Thakar, A. Lowe, F. Ladha, A. Pettinato, E. Meredith, Y.-s. Chen, K. Atamanuk, B. Huey, J. T. Hinson

This study uses CRISPR/Cas9 to create HCM iPSc models and finds that mutations cause hypercontractility and p53 activation linked to oxidative stress, suggesting p53 as a therapeutic target.

bioRxiv · Sep 4, 2018Cell Biology