E. Forte

Podoplanin Positive Cell-derived Extracellular Vesicles Contribute to Cardiac Amyloidosis After Myocardial Infarction

This study identifies that Podoplanin-expressing mesenchymal stromal cells release exosomes that trigger SAA3 overproduction in macrophages, leading to cardiac amyloidosis after myocardial infarction.

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

The paper uses genetically diverse mice to model varied innate immune responses to SARS-CoV-2 infection, showing differences in survival, viral replication, and cytokine profiles.

Adult fibroblasts retain organ-specific transcriptomic identity

This study shows fibroblasts retain organ-specific transcriptomic identity across development, culture, and transplants, with implications for targeted fibrotic disease treatment.

Myocardial damage induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart.

This study shows that a single high dose of isoproterenol in mice causes myocardial damage and a persistent adaptive immune response against the heart, making it a suitable model for studying anti-heart autoimmunity.

PDGFR alpha signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

This study investigates how PDGFR alpha signaling in cardiac fibroblasts affects quiescence, metabolism, and self-renewal, leading to improved heart repair after myocardial infarction.

TNF-α induces reactivation of human cytomegalovirus independently of myeloid cell differentiation following post-transcriptional establishment of latency

This study shows HCMV establishes latency post-transcriptionally in myeloid progenitor cells and TNF-α induces reactivation without requiring myeloid differentiation.