Author

A. O. Gramolini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

C. A. Simmons· 2 shared N. I. Callaghan· 2 shared S.-H. Lee· 2 shared U. Kuzmanov· 2 shared A. C. T. Teng· 1 shared A. C. Teng· 1 shared A. Deyawe Kongmeneck· 1 shared A. Driouchi· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBioengineering

C. A. Simmons

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of cardiac calcium handling

S. R. Cleary, A. C. Teng, A. Deyawe Kongmeneck, X. Fang, T. A. Phillips, E. E. Cho, P. M. Kekenes-Huskey, A. O. Gramolini, S. L. Robia

This study shows that the R14del mutation in phospholamban increases pentamer stability, reducing its ability to regulate SERCA and impairing cardiac calcium handling during physiological stress.

bioRxiv · May 26, 2023 · PreprintPhysiology

Advanced physiological maturation of iPSC-derived human cardiomyocytes using an algorithm-directed optimization of defined media components

N. I. Callaghan, L. J. Durland, W. Chen, U. Kuzmanov, M. Z. Miranda, Z. Mirzaei, R. G. Ireland, E. Y. Wang, K. Wagner, M. M. Kim, J. Audet, P. Santerre, A. O. Gramolini, F. Billia, M. Radisic, , C. A. Simmons

This study develops a novel medium for iPSC-derived cardiomyocytes using differential evolution to enhance maturation, validated through multiomic analysis.

bioRxiv · Oct 10, 2022Bioengineering

Phosphoproteomic analysis of chondrocytes after short-term exposure to inorganic polyphosphate

U. Kuzmanov, R. Gawri, A. Zelinka, K. A. Russel, S.-H. Lee, A. O. Gramolini, R. Kandel

This study uses phosphoproteomic analysis to identify key proteins involved in chondrocyte metabolism after exposure to inorganic polyphosphate.

bioRxiv · Jul 30, 2021 · PreprintBioengineering

An Efficient and Cost-effective Purification Methodology for Cas9 Nuclease

A. C. T. Teng, M. Tavassoli, S. Shrestha, K. Lindsay, E. Ivakine, R. Cohn, J. P. Santerre, A. O. Gramolini

This paper introduces a rapid, efficient, and cost-effective method to purify active SaCas9 protein with over 90% purity within 24 hours.

bioRxiv · Jun 8, 2021 · PreprintBiochemistry

Long-term functional culture and in vitro manipulation of adult mouse cardiomyocytes

N. I. Callaghan, S.-H. Lee, S. Hadipour-Lakmehsari, X. A. Lee, M. A. Siraj, A. Driouchi, C. M. Yip, M. Husain, C. A. Simmons, A. O. Gramolini

This study develops methods to culture adult mouse cardiomyocytes long-term, maintaining their structure and function for in vitro experiments and genetic manipulations.

Communications Biology · May 11, 2020Peer-reviewedCell Biology