Author

R. D. A. Wilkinson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

D. I. Johnston· 1 shared D. P. Harkin· 1 shared E. E. Parkes· 1 shared E. M. Barros· 1 shared K. I. Savage· 1 shared K. Lappin· 1 shared N. McCabe· 1 shared R. Ali· 1 shared

Activity by Year

2019-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

D. I. Johnston

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1 paper

Recent·Most cited

Topoisomerase II inhibitors induce cGAS-STING dependent inflammation resulting in cytokine induction and immune checkpoint activation

R. D. A. Wilkinson, N. McCabe, E. E. Parkes, E. M. Barros, D. I. Johnston, R. Ali, K. Lappin, R. Greenberg, D. P. Harkin, S. A. McIntosh, R. D. Kennedy, K. I. Savage

This study shows topo-II inhibitors like doxorubicin induce cGAS-STING dependent inflammation, cytokine production, and immune checkpoint activation in cancer cells, enhancing potential for immune checkpoint blockade therapy.

bioRxiv · Oct 24, 2019 · PreprintCancer Biology