Author

E. E. Parkes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

R. D. Kennedy· 2 shared A. Carracedo· 1 shared A. J. Ryan· 1 shared A. Orlova· 1 shared A. Tracz· 1 shared A. Varady· 1 shared B. Hantusch· 1 shared B. Wingelhofer· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

R. D. Kennedy

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4 papers

Recent·Most cited

Radiation-induced persistent DNA damage response and late toxicity in cardiac tissue

K. Shigemori, Y. Jiang, J. C. Martin, M. A. Hawkins, A. J. Ryan, E. E. Parkes

This study investigates early and late cardiac toxicity in irradiated A/J mice, identifying persistent DNA damage and macrophage polarization as potential contributors to long-term cardiac complications.

bioRxiv · Feb 27, 2023 · PreprintCancer Biology

STAT3 restricts prostate cancer metastasis and antiandrogen resistance by controlling LKB1/CREB signaling pathway

J. Pencik, C. Philippe, M. Schlederer, M. Pecoraro, S. Grund-Groeschke, W. J. Li, A. Tracz, I. Heidegger, S. Lagger, K. Trachtova, M. Oberhuber, E. Heitzer, O. Osman, H. A. Neubauer, B. Wingelhofer, , C. McKinney

This study identifies STAT3's role in restricting prostate cancer metastasis and antiandrogen resistance by regulating the LKB1/CREB signaling pathway in mouse models and human patients.

bioRxiv · Aug 25, 2022 · PreprintCancer Biology

The clinical and molecular significance associated with STING signaling in estrogen receptor-positive early breast cancer

E. E. Parkes, M. P. Humphries, E. Gilmore, F. A. Sidi, V. Bingham, S. M. Phyu, S. G. Craig, C. Graham, J. Miller, D. Griffin, R. D. Kennedy, S. F. Bakhoum, S. McQuaid, M. Salto-Tellez, N. E. Buckley

The paper identifies perinuclear STING (pnSTING) in ER+ breast cancer as a prognostic marker linked to immune infiltration and poor outcomes in low pnSTING tumors.

bioRxiv · Jul 23, 2020Cancer Biology

Topoisomerase II inhibitors induce cGAS-STING dependent inflammation resulting in cytokine induction and immune checkpoint activation

R. D. A. Wilkinson, N. McCabe, E. E. Parkes, E. M. Barros, D. I. Johnston, R. Ali, K. Lappin, R. Greenberg, D. P. Harkin, S. A. McIntosh, R. D. Kennedy, K. I. Savage

This study shows topo-II inhibitors like doxorubicin induce cGAS-STING dependent inflammation, cytokine production, and immune checkpoint activation in cancer cells, enhancing potential for immune checkpoint blockade therapy.

bioRxiv · Oct 24, 2019 · PreprintCancer Biology