Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control
R. D. Mouery, C. Hsu, T. Bonacci, D. L. Bolhuis, X. Wang, C. A. Mills, E. D. Toomer, O. G. Canterbury, K. C. Robertson, T. B. Branigan, N. G. Brown, L. E. Herring, M. Emanuele
The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.
bioRxiv · Oct 11, 2023 · PreprintCell Biology