Author

C. A. Mills

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

L. E. Herring· 4 shared A. E. Adams· 1 shared A. Ghoshal· 1 shared A. Khan· 1 shared A. L. Brademeyer· 1 shared A. L. Mordant· 1 shared B. D. Strahl· 1 shared B. J. Henriques· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersCell Biology

L. E. Herring

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

E. M. Merten, J. D. Sears, T. M. Leisner, P. B. Hardy, A. Ghoshal, M. A. Hossain, K. H. Asressu, P. J. Brown, M. A. Stashko, L. E. Herring, A. L. Mordant, T. S. Webb, C. A. Mills, N. K. Barker, J. J. Arnold, , K. H. Pearce

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

bioRxiv · Mar 22, 2024 · PreprintBiochemistry

APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest

B. L. Mouery, E. M. Baker, C. A. Mills, L. E. Herring, D. Fleifel, J. G. Cook

This paper shows APC/C activity is essential to maintain CDK4/6 inhibitor-induced arrest by preventing premature S phase entry through degradation of cyclin A.

bioRxiv · Nov 9, 2023 · PreprintCell Biology

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

R. D. Mouery, C. Hsu, T. Bonacci, D. L. Bolhuis, X. Wang, C. A. Mills, E. D. Toomer, O. G. Canterbury, K. C. Robertson, T. B. Branigan, N. G. Brown, L. E. Herring, M. Emanuele

The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.

bioRxiv · Oct 11, 2023 · PreprintCell Biology

SETD2 maintains nuclear lamina stability to safeguard the genome

A. Khan, J. M. Metts, L. C. Collins, C. A. Mills, K. Li, A. L. Brademeyer, B. M. Bowman, M. B. Major, J. Aube, L. E. Herring, I. J. Davis, B. D. Strahl

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

bioRxiv · Sep 28, 2023Cell Biology

Deglutarylation of GCDH by SIRT5 controls lysine metabolism in mice

D. P. Bhatt, C. A. Mills, K. A. Anderson, B. J. Henriques, T. G. Lucas, S. Francisco, J. Liu, O. R. Ilkayeva, A. E. Adams, S. R. Kulkarni, D. S. Backos, P. A. Grimsrud, C. M. Gomes, M. D. Hirschey

This study identifies glutarylation of GCDH by glutaryl-CoA and shows SIRT5 deglutarylates GCDH, restoring its function and regulating lysine metabolism in mice.

bioRxiv · Jun 28, 2020 · PreprintBiochemistry