L. E. Herring

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics

This study shows TRIM9 localizes to dendritic spines and regulates actin dynamics and synaptic responses to netrin-1 during synaptogenesis.

APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest

This paper shows APC/C activity is essential to maintain CDK4/6 inhibitor-induced arrest by preventing premature S phase entry through degradation of cyclin A.

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.

SETD2 maintains nuclear lamina stability to safeguard the genome

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

Multi-monoubiquitination controls VASP-mediated actin dynamics

This study shows that multi-monoubiquitination of VASP at specific lysine residues negatively regulates its actin-binding and bundling activities, affecting cell spreading morphology.

Calpain-mediated proteolysis of vimentin filaments is augmented in Giant Axonal Neuropathy (GAN) fibroblasts exposed to hypotonic stress

This study shows that hypotonic stress increases calpain-mediated vimentin proteolysis in GAN fibroblasts, which is more pronounced than in controls.

Perilipin 5 interacts with Fatp4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport

This study identifies Plin5 and Fatp4 interaction at LD-mitochondria contacts, showing phosphorylation of Plin5 and Fatp4's role in fatty acid transport during starvation.

The ataxia protein sacsin is required for integrin trafficking and synaptic organization

This study identifies sacsin's role in integrin trafficking and synaptic organization, showing its deficiency causes cellular phenotypes in ARSACS.

Defining the KRAS-regulated kinome in KRAS-mutant pancreatic cancer

This study identifies upregulated and downregulated kinases in KRAS-mutant pancreatic cancer using chemical proteomics, revealing potential therapeutic targets.