Novel determinant of antibiotic resistance: a clinically selected Staphylococcus aureus clpP mutant survives daptomycin treatment by reducing binding of the antibiotic and adapting a rod-shaped morphology
L. Xu, C. Henriksen, V. H. Mebus, R. Guerillot, A. Petersen, N. Jacques, J.-H. Jiang, R. Derks, E. Sanchez-Lopez, M. Giera, K. Leeten, T. P. Stinear, C. Oury, B. P. Howden, A. Y. Peleg, D. Frees
The paper identifies a clpP SNP mutation in MRSA that reduces daptomycin binding and enables survival through rod-shaped morphology, contributing to antibiotic resistance.
bioRxiv · Mar 6, 2023 · PreprintMicrobiology