M. Giera

Fatty acid desaturation and lipoxygenase pathways support trained immunity

This study identifies fatty acid desaturation and lipoxygenase pathways as essential for BCG-induced trained immunity in human monocytes.

The ORP9-ORP11 dimer promotes sphingomyelin synthesis

The paper identifies the ORP9-ORP11 dimer as critical for sphingomyelin synthesis by exchanging phosphatidylserine and phosphatidylinositol-4-phosphate at ER-Golgi contact sites.

Novel determinant of antibiotic resistance: a clinically selected Staphylococcus aureus clpP mutant survives daptomycin treatment by reducing binding of the antibiotic and adapting a rod-shaped morphology

The paper identifies a clpP SNP mutation in MRSA that reduces daptomycin binding and enables survival through rod-shaped morphology, contributing to antibiotic resistance.

Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: a randomized cross-over trial

This study shows cold exposure increases circulating free fatty acids and transiently lowers total triacylglycerols in humans, with dynamic changes in TAG species dependent on saturation and chain length, and this effect is mediated by intracellular lipolysis.

Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

This study shows that SCD1 inhibits Treg differentiation and promotes autoimmunity by affecting fatty acid metabolism in an MS model.

Fasciola hepatica Fatty Acid Binding Protein 1 modulates T cell polarization by promoting dendritic cell thrombospondin-1 secretion without affecting metabolic homeostasis in obese mice

Generating heterokaryotic cells via bacterial cell-cell fusion

This study generates heterokaryotic bacterial cells through controlled cell-cell fusion using synthetic lipopeptides, revealing membrane fluidity and specificity as key factors.

Asymptomatic gut colonization by extended-spectrum beta-lactamase-producing Escherichia coli is not associated with an altered gut microbiome or metabolome in Dutch adults

This study finds that asymptomatic gut colonization by ESBL-producing E. coli in Dutch adults is not linked to changes in microbiome or metabolome composition.

Lipid mediator profile of burn wound healing: Acellular cod fish skin grafts promote the formation of EPA and DHA derived lipid mediators during the first seven days

This study examines how acellular fish skin grafts affect lipid mediator formation in burn wounds, finding increased EPA and DHA derivatives and reduced pain-related mediators within seven days.

METLIN Neutral Loss Database Enhances Similarity Analysis

The paper introduces the METLIN neutral loss database to enhance structural similarity analysis of molecules using MS2 data.

A squalene-hopene cyclase in Schizosaccharomyces japonicus represents a eukaryotic adaptation to sterol-independent anaerobic growth

This study identifies a squalene-hopene cyclase in Schizosaccharomyces japonicus that enables sterol-independent anaerobic growth by synthesizing hopanoids as sterol surrogates.

Intestinal transkingdom analysis on the impact of antibiotic perturbation in health and critical illness

The paper analyzes the impact of antibiotic perturbation on intestinal transkingdom interactions in health and critical illness using multi-omics data.

Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacterxylosoxidans

The paper identifies Axc, a novel beta-lactamase with carbapenemase activity, in a meropenem-resistant Achromobacter xylosoxidans isolate using proteomics and confirms its role in resistance.