Author

R. Guerillot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

B. P. Howden· 5 shared T. P. Stinear· 5 shared G. P. Carter· 3 shared I. R. Monk· 3 shared S. J. Pidot· 3 shared A. Goncalves da Silva· 2 shared A. Hachani· 2 shared C. J. Walsh· 2 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersMicrobiology

B. P. Howden

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Author profile →

5 papers

Recent·Most cited

Novel determinant of antibiotic resistance: a clinically selected Staphylococcus aureus clpP mutant survives daptomycin treatment by reducing binding of the antibiotic and adapting a rod-shaped morphology

L. Xu, C. Henriksen, V. H. Mebus, R. Guerillot, A. Petersen, N. Jacques, J.-H. Jiang, R. Derks, E. Sanchez-Lopez, M. Giera, K. Leeten, T. P. Stinear, C. Oury, B. P. Howden, A. Y. Peleg, D. Frees

The paper identifies a clpP SNP mutation in MRSA that reduces daptomycin binding and enables survival through rod-shaped morphology, contributing to antibiotic resistance.

bioRxiv · Mar 6, 2023 · PreprintMicrobiology

The two-component regulator WalKR provides an essential link between cell wall homeostasis with DNA replication in Staphylococcus aureus

L. K. R. Sharkey, R. Guerillot, C. J. Walsh, A. M. Turner, J. Y. H. Lee, S. L. Neville, S. Klatt, S. L. Baines, S. J. Pidot, F. J. Rossello, T. Seeman, H. McWilliam, E. Cho, G. P. Carter, B. P. Howden, , I. R. Monk

This study identifies the WalKR two-component system in Staphylococcus aureus as a polyfunctional regulator linking cell wall homeostasis with DNA replication and other essential processes.

bioRxiv · Feb 27, 2023 · PreprintMicrobiology

A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

A. Hachani, S. G. Giulieri, R. Guerillot, C. J. Walsh, M. Herisse, Y. M. Soe, S. L. Baines, D. R. Thomas, S. D. Cheung, A. S. Hayes, H.-J. Cho, H. J. Newton, S. Pidot, R. C. Massey, B. P. Howden, T. P. Stinear

The paper develops a high-throughput platform to identify S. aureus mutations that enhance intracellular persistence and reduce cytotoxicity, revealing agr-independent pathoadaptive mutations.

bioRxiv · Dec 11, 2022Microbiology

Functional genomics reveals extensive diversity in Staphylococcus epidermidis restriction modification systems compared to Staphylococcus aureus.

J. Y. Lee, G. P. Carter, S. J. Pidot, R. Guerillot, T. Seeman, A. Goncalves da Silva, T. J. Foster, B. P. Howden, T. P. Stinear, I. R. Monk

The paper identifies extensive diversity in type I restriction modification systems in Staphylococcus epidermidis compared to Staphylococcus aureus, enabling efficient genetic manipulation of clinically relevant strains.

bioRxiv · May 22, 2019 · PreprintMicrobiology

Increasing tolerance of hospital Enterococcus faecium to hand-wash alcohols

S. J. Pidot, W. Gao, A. H. Buultjens, I. R. Monk, R. Guerillot, G. P. Carter, J. Y. H. Lee, M. M. C. Lam, S. A. Ballard, M. L. Grayson, A. A. Mahony, E. A. Grabsch, D. Kotsanas, T. Korman, G. W. Coombs, , T. P. Stinear

The paper shows hospital Enterococcus faecium isolates from 2010 onward are 10-fold more tolerant to alcohol-based disinfectants than older isolates, leading to increased gastrointestinal colonization in mice.

bioRxiv · May 16, 2016Microbiology