Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia.
G. Parriott, E. Hegermiller, R. E. Morman, C. Frank, C. Saygin, W. Stock, E. T. Bartom, B. L. Kee
This study shows that E2a suppresses T-ALL by promoting T cell development and inter-thymocyte competition, preventing leukemogenesis.
bioRxiv · Apr 23, 2023 · PreprintCancer Biology